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Reclast (zoledronic acid) injection. These side effects dont occur with infusions. Our team of healthcare professionals is committed to making the experience as comfortable as possible. (2017). Zometa is approved by the Food and Drug Administration (FDA) to treat: Zometa is not approved for use in children. Thank you, {{form.email}}, for signing up. However, Reclast has different approved uses than those of Zometa. Your cancer treatment may include chemotherapy, radiation therapy, hormone therapy, or targeted therapy. These are called bone metastases. They work by interfering with the cells that break down bone and lead to increased bone mass and strength over time. What is zoledronic acid? So its critical to maintain high vitamin D and calcium levels before taking this medication. Zometa is approved to treat the following conditions* in adults: Calcium is a mineral thats stored in your bones, and it helps to keep your bones strong. Coping with cancer can be difficult. The drug lowers the risk for spinal cord compression and the need for radiation therapy or surgery to the bones. You can learn more about how we ensure our content is accurate and current by reading our. Some studies have shown that vertebroplasty can relieve pain in up to 9 out of 10 people (up to 90%) with myeloma or other types of cancer that have spread (metastatic cancers). Some people have had atypical femur (thigh bone) fractures while having treatment with Zometa. In addition to the uses listed above, Zometa may also be used off-label for other conditions. NICE has issued guidance on vertebroplasty for treating fractures in people with painful conditions of the spine, including tumours. These drugs not only reduce the risk of fractures (a common complication) but may, in some cases, improve survival. Drink at least 2 glasses of water within a few hours before your injection to keep from getting dehydrated. This is if bisphosphates didnt work well enough or you couldnt use them. Let's look at why and what you can do. Experts estimate that osteoporosis affects more than 10 million people in the United States over the age of 50. Youre unlikely to notice the drug working. Otherwise, call a poison control center right away. It is given as an injection every month at your doctor's office and is limited to one year of treatment. If you think youve taken too much of this drug, call your doctor. When you first visit one of our facilities, you will meet with one of our healthcare professionals to discuss your medication, the duration of each infusion treatment, and the side effects. Osteonecrosis of the jaw has been reported in people having treatment with intravenous (IV) bisphosphonates, including Zometa. If youre sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while youre using Zometa. Its typically done at a healthcare facility, but in some cases, a healthcare provider may give you the drug in your home. The side effects of this reaction can include flu-like symptoms, such as: The symptoms typically ease in a few days. (See also How to Use section.). Types of cancer that this happens with include lung cancer, head and neck cancer, kidney cancer, and ovarian cancer. Your kidney function may also need to be checked. Is the ketogenic diet right for autoimmune conditions? But its not meant as a regular long-term treatment. The power to infuse bones into objects (usually weapons), beings, or powers. Certain prescription steroids may cause osteoporosis by how your body accesses its stores of calcium and vitamin D. Osteoporosis and degenerative disk disease (DDD) are unique conditions that may be related. By clicking Accept All Cookies, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Generic name: zoledronic acid [ZOE-le-DRON-ik-AS-id] (2021). However, some may turn into cancerous tumors. Prolia can lower the amount of calcium your body contains. To help make sure you dont miss a dose, try setting a reminder on your phone for your appointments. If your blood calcium level doesnt fall to a normal level within 7 days, you may need a second dose of Zometa. Our website services, content, and products are for informational purposes only. Bisphosphonates are a group of medicines that are given intravenously (IV) for numerous bone disorders including Osteoporosis and Pagets Disease. Bone metastases from solid tumors are cancers that have spread from their original site to your bones. Zoledronic acid - Drug summary. Z. 2023 Healthline Media UK Ltd, Brighton, UK. Each infusion takes about 15 to 30 seconds. It is also given every two years as an IV infusion to prevent osteoporosis. Zoledronic acid is also used with cancer chemotherapy to treat bone problems that may occur. Some products that may interact with this drug include: calcium-containing IV fluids, "water pills" (diuretics such as bumetanide, furosemide). For instance, some interactions can interfere with how well a drug works. Zometa contains zoledronic acid. Consult your pharmacist or local waste disposal company. Zometa is also absorbed into the osteoclasts, stopping them from working. While any bisphosphonates can cause osteonecrosis, 94% of cases are in people who've had it in high-dose IV form, not in doses given for osteoporosis. Bisphosphonate therapy. These bisphosphonates work by inhibiting farnesyl pyrophosphate synthase. To keep benefitting from Zometa, youll need to have an infusion every 3 to 4 weeks. It's also used to increase bone mass for patients with specific types of cancer. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Bisphosphonates, on the other hand, are drugs that help prevent the breakdown of bone. Its critical that you not take this drug if youve had a stroke or heart attack in the past year. Whats the Relationship Between Anorexia and Osteoporosis? Zometa contains zoledronic acid. Zometa can help prevent bone metastases in females* who have gone through menopause, either naturally or following treatment for their cancer. But this wasnt reported in clinical trials of Zometa. You should not use Reclast and Zometa at the same time. Below is information about other possible uses for Zometa. She completed the certified APhA Delivering Medication Therapy Management Services course. Also tell your doctor or pharmacist of drugs that may be harmful to your kidneys such as: aminoglycoside antibiotics (including gentamicin, tobramycin), amphotericin B, nonsteroidal anti-inflammatory drugs (NSAIDs such as ibuprofen), tacrolimus. These lists contain up to 10 of the most common mild side effects that can occur with either Zometa or Prolia, as well as mild side effects that both drugs may share. Find information on cost and zoledronic acid, how generic and brand-name prices compare, what financial assistance is available, and more. Keep all medications away from children and pets. Other treatment options for osteoporosis include denosumab, HRT, salmon calcitonin, and synthetic PTH. You can receive Prolia through IV injections every six months. A fracture is a break in the continuity of a bone. This is a high level of calcium in your blood thats caused by cancer. For more information, please, Personalized Hematology-Oncology & Primary Care, Sickle Cell Anemia Treatments and Tips for a Healthy Lifestyle, Coping With Cancer Through Stress Management, Multiple Sclerosis Treatment with Infusions, MARKETING WEBSITE BY GROUP3 COMMUNICATIONS. These treatments include chemotherapy or radiation therapy. Those bones often rebuild themselves but cant always keep up the pace, so the bones become weaker. (Multiple myeloma is a form of cancer that affects the bone marrow tissue inside your bones.). Zometa is given by intravenous (IV) infusion. Adverse effects of zoledronic acid may include: A small number of individuals who receive intravenous bisphosphonate therapy may also experience: Other treatment options available to help treat osteoporosis may include: Denosumab is a bone anti-resorptive drug. If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Zometa isnt approved for any uses in children. (2019). Ganesan K, et al. Do not use Zometa if you are pregnant. But, this drug is normally well tolerated. The dose may need to be repeated depending on your blood calcium levels. Can diet and exercise reverse prediabetes? This medication comes as a shot that you must receive daily and take for at least two years. Some people who are sensitive to aspirin have had asthma attacks when treated with a bisphosphonate drug. The typical Zometa dosage for adults with multiple myeloma or bone metastases from solid tumors is 4 mg, given every 3 to 4 weeks. This medication can also increase the risk of a stroke, heart attack and even death. If daily or weekly pills to treat osteoporosis arent a good fit for you, you may be able to receive quarterly or yearly infusions. The costs of Zometa and Xgeva will vary depending on your treatment plan. (2017). As with all medications, the cost of Zometa can vary. This is an off-label use of the drug. Long-term use of denosumab is more likely than bisphosphonates to cause a low calcium level. These are typically given on days 8 and 15 of the first month of treatment. Zometa is used to treat high blood levels of calcium caused by cancer (also called hypercalcemia of malignancy). Other treatments (such as radiation therapy) are usually needed, as are medications to control pain. Studies in animals found that the drug can harm a developing fetus and cause miscarriage. Byun J-H, et al. Percutaneous vertebroplasty and percutaneous balloon kyphoplasty for treating osteoporotic vertebral compression fractures, National Institute for Health and Care Excellence, 2013, Percutaneous cementoplasty for palliative treatment of bony malignancies (Interventional procedures guidance), National Institute for Health and Care Excellence, 2006, Oxford Textbook of Palliative Medicine (5th edition), Denosumab for the prevention of skeletal-related events in adults with bone metastases from solid tumours If you drink alcohol, ask your doctor how much is safe to have when receiving Zometa. This leads to damage to your jawbone. About 30% of people experience flu-like symptoms after their first infusion. It is important to get each dose of this medication as scheduled. Medication and treatment adherence. ", Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. If youre breastfeeding or plan to breastfeed, talk with your doctor about treatment options other than Zometa. Zometa infusions take at least 15 minutes. As you age especially after menopause bones break down more quickly. Doctors reserve them for people with severe osteoporosis. Diuretics can also cause problems that affect how well your kidneys work. Bisphosphonates are a group of drugs that can be used to help protect bones against the effects of some cancers and to treat some bone conditions. (An IV infusion is an injection into a vein thats given slowly over a period of time.). Infusion therapy allows for the direct injection of medication into the bloodstream and the cardiovascular system. Selected from data included with permission and copyrighted by First Databank, Inc. Mild side effects of Zometa can include:*. Doctors have used them to treat osteoporosis since the 1990s. In addition, the price depends on the cost of the healthcare provider visits to receive doses of either drug. That protein regulates the breaking down of bones and repair. At Infusion Associates, we provide medically-prescribed infusion therapy for patients with chronic conditions in a welcoming and friendly environment. (To learn more, see the Zometa side effects section above.) These include kidney problems and osteonecrosis (death of bone cells) of the jaw. Download our fact sheet Zoledronate Zoledronate is a type of medication called a bisphosphonate. This medicine also treats multiple myeloma (a type of bone marrow cancer) or bone cancer that has spread from elsewhere in the body. Zometa may not be right for you if you have certain medical conditions or other factors affecting your health. You should not breastfeed while using Zometa. Before using zoledronic acid, tell your doctor or pharmacist if you are allergic to it; or to other bisphosphonates (such as alendronate, risedronate); or if you have any other allergies. After you stop taking any of these bone-building medications, you generally will need to take another osteoporosis drug to maintain the new bone growth. Find out about the emotional, physical and practical effects of cancer and how to manage them. Get medical help right away if you have any serious side effects, including: signs of kidney problems (such as change in the amount of urine), seizures. Privacy Policy | Designed by Forge. If you use Zometa with aminoglycoside antibiotics, your risk for these problems may be higher. Zometa is not metabolized and is excreted as an unchanged drug via the kidneys. Osteoclasts are molecules in the body that are responsible for bone resorption, which is the process where osteoclasts break down and remove bone. Some women take this medication for more than five years. * Use of the term male or female in this article refers to a persons sex assigned at birth. Data sources include IBM Watson Micromedex (updated 14 May 2023), Cerner Multum (updated 28 May 2023), ASHP (updated 10 Apr 2023) and others. These lists contain up to 10 of the most common mild side effects that can occur with either Zometa or Xgeva, as well as mild side effects that both drugs may share. Its not known how often this may have occurred in clinical studies of the drug. Multiple myeloma is a form of cancer that affects the bone marrow tissue inside your bones. These include: These bone-modifying agents can help people with cancer in several ways: Bone-modifying agents are recommended for anyone with breast cancer that's spread to the bone and are frequently used with other solid tumors (such as lung cancer). Other drugs may interact with zoledronic acid, including prescription and over-the-counter medicines, vitamins, and herbal products. It can help to relieve pain and make the bone more stable. A doctor will inject the medication into the body either through a needle or a catheter, which is a tube. Properly discard this product when it is expired or no longer needed. A fever will usually get better in a few days. If youre interested in using the generic form of Zometa, talk with your doctor. But ibandronate was typically more affordable. These drugs can cause hypocalcemia (a low level of calcium in your blood). You may need to have a negative pregnancy test before starting treatment with Zometa. Symptoms of this condition may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. Doctors can treat weakened bones affected by cancer by using either medicines or surgery. If youre not sure if youll need to get prior authorization for Zometa, contact your insurance company. Role of side effects, physician involvement, and patient perception in non-adherence with oral bisphosphonates. Bisphosphonates help to prevent the breakdown of bone. With this condition, bone cells in your jawbone die, leading to damage to your jawbone. The most common bisphosphonates are alendronate, ibandronate, risedronate and zoledronic acid. (A class of drugs is a group of medications that work in a similar way.) Affiliated provider with Southern Cross, and other insurance providers, Ponsonby Specialist Centre, Increasing Bone Density. Bone-strengthening drugs for cancer are now available. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. All treatments follow strict infection control protocols at each stage of administration. This is called non-tumor-related hypercalcemia. The epidemiology of osteoporosis. But in some cases, you can receive the injections from a healthcare provider at home or be trained how to give yourself injections. In many cases, they can be used as soon as bone metastases are diagnosed. Or they may have you switch to a different drug. Collagen plays an important part in bone mass. This leads to hypercalcemia. Atypical femur fractures have also been reported in people having treatment with other bisphosphonates. By slowing bone breakdown, Zometa can also make it harder for the cancer to grow in your bones. There are two techniques: Cementoplasty means using a special cement to strengthen and support bone. They can tell you if it comes in forms and strengths that can be used for your condition. Learn about the different types of benign. This affects the structure and strength of bones and makes fractures more likely. Thumbigere-Math V, Michalowicz BS, Hodges JS, et al. Zometa helps reduce bone damage and bone pain that can occur when cancer forms in your bones. These tests are used to check your calcium level and kidney function. * This is a partial list of mild side effects from Zometa. Bisphosphonates are a class of drugs that can help treat osteoporosis in all individuals. Living with a chronic health condition affects so many areas of your life the chronic pain can be debilitating, your new fragility makes it difficult to do your usual activities, and the reality of all of it can be emotionally draining. National Institute for Health and Care and Excellence (NICE) Technology appraisal guidance, 2012, Vertebroplasty and Kyphoplasty for the Palliation of Pain. In addition, you should have regular dental exams to check for any problems. Your doctor will determine how long to treat you with this medicine. The actual price youll pay for either drug also depends on your insurance plan, your location, and the pharmacy you use. Both work towards the goal of strengthening your bones and reducing fractures. Zometa bottles and vials should be stored at 77F (25C). Aminoglycosides are a specific type of antibiotic. Zometa lowers the level of calcium in your blood. You may need a second infusion if your calcium level isnt back to normal within 7 days. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. If you have bone, joint, or muscle pain while receiving Zometa, talk with your doctor. Throughout your life, healthy bones continuously break down and rebuild. Two primary classes of drugs are used to treat bone metastases. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. There are many options for osteoporosis infusion treatment, and one of them is right for you. Treatment options include a combination of surgery, rinses, antibiotics, and hyperbaric oxygen treatments. (Multiple myeloma is a form of cancer that affects the marrow inside your bones.). Zometa is a bisphosphonate medicine that alters bone formation and breakdown in the body. It also looks at what to expect and when a doctor may recommend them. And generics tend to cost less than brand-name drugs. If needed, this may be repeated after 7 days. Calcium and vitamin D: Important at every age. Many drugs available today can slow the rate of bone loss and can rebuild bone strength. The Reclast brand of zoledronic acid is used in men and women to treat or prevent osteoporosis caused by menopause or by taking steroids. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Both bisphosphonates and denosumab appear to have significant anti-cancer activity. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Avoiding these side effects can allow you to receive all the helpful benefits of the treatments quickly. Zometa is used to treat high blood levels of calcium caused by cancer (also called hypercalcemia of malignancy). The risk is highest in people with cancer, blood cell disorders, pre-existing dental problems, or people treated with steroids, chemotherapy, or radiation. And if you have cancer growing in your bones, this can cause your bones to have further damage, weakness, and pain. Some people have a short-term reaction within the first 3 days of receiving Zometa. Use: Treatment of hypercalcemia of malignancy (albumin-corrected calcium equal 12 mg/dL or greater). Over the course of the studies, bone issues occurred in: * Pamidronate belongs to the same class of drugs as Zometa. Zoledronic acid belongs to a group of drugs called bisphosphonates. This medication is used to treat high blood calcium levels (hypercalcemia) that may occur with cancer. For the treatment of multiple myeloma and bone problems caused by the spread of cancer, this medication is usually given every 3 to 4 weeks or as directed by your doctor. Serious side effects and their symptoms can include: * For more information on these side effects, see Side effect details below. Prior to the infusion of Bisphosphates, you need to be adequately hydrated, and staying hydrated after the infusion is very important. (A class of drugs is a group of medications that work in a similar way.). However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Talk to your pharmacist for more details. But if they become more severe or dont go away, talk with your doctor or pharmacist. (In general, a normal blood calcium level in adults is between 8.6 mg/dL and 10.2 mg/dL. This article looks at the new drugs for bone metastases, how they work, and other possible treatments. More research is needed to understand its long-term effectiveness and safety. Heres how often bone problems occurred in each group: Xgeva hasnt been directly compared with Zometa for treating hypercalcemia caused by cancer. You are also welcome to bring your own snacks and beverages of choice. Here are the percentages of people who had bone pain, muscle pain, or joint pain: Bone, muscle, or joint pain may be part of a short-term reaction that can develop in the first few days after receiving Zometa. J Oncol Pract. Biologics, on the other hand, cant be copied exactly. Finally, you can take zoledronic acid yearly through an IV. Before being treated with Zometa, you should have a dental checkup. To help cut the side effects, try experimenting with doses and regimens. Its not known if Zometa passes into breast milk or if the drug affects the way your body makes breast milk. By slowing bone breakdown, Zometa can also make it harder for cancer to grow in your bones. How Are Osteoporosis and Degenerative Disc Disease Related? Yes! You may have a higher risk for osteonecrosis of the jaw if you: During your Zometa treatment, see your doctor right away if you have dental problems or symptoms of osteonecrosis of the jaw. But throughout your life, your bones are constantly being rebuilt by cells called osteoclasts and osteoblasts. There are two techniques: percutaneous cementoplasty vertebroplasty and kyphoplasty Percutaneous cementoplasty Cementoplasty means using a special cement to strengthen and support bone. A healthcare provider gives zoledronic acid as an intravenous (IV) dose of 5 mg in a doctor's office or other outpatient setting. This group of drugs prevents bone loss by inhibiting your body's resorption of bone tissue. Zoledronic acid can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, high blood pressure, or pain or arthritis (including Advil, Motrin, and Aleve). Zometa is contraindicated in people with known hypersensitivity to any ingredient. They can help you decide whether Zometa or a different drug is right for you. Zometa helps strengthen bones and prevent their breakdown, so you may wonder if the drug can be used for these conditions. Tell them about all prescription, over-the-counter, and other drugs you take. It treats fractures of the spine. And if you have questions about Zometa or Reclast, talk with your doctor. 2023 Healthline Media LLC. To learn about other mild side effects, talk with your doctor or pharmacist, or visit Zometas prescribing information. It comes as a capsule. The drug remains stable with temporary short-term storage from 59F to 86F (15C to 30C). You can take alendronate daily or weekly. And you may wonder if Zometa is used for certain other conditions. Tell your doctor about all your current medicines and any medicine you start or stop using. You may also be instructed to take calcium and vitamin D supplements each day. This medication may stay in your body for many years. Zometa 4 Mg Intravenous Powder For Solution, Enter your medication into the WebMD interaction checker, prevention of skeletal related events in multiple myeloma, prevention of skeletal related events associated with bone metastases from solid tumor, increased calcium in the blood from cancer, loss of bone mineral density (BMD) due to anti-androgen drug, FDA Labeling for Zometa intravenous on RxList. While using this medication, you should not be treated with other bisphosphonates, including other brands of zoledronic acid used to prevent or treat bone loss (osteoporosis). You can take risedronate daily, weekly or monthly. You should not become pregnant while using zoledronic acid. For more information on this side effect, see Side effect details below. If your calcium level increases again, the treatment can be repeated. If you have any questions about how Zometa will treat your condition, talk with your doctor. These are drugs that may be expensive or may require help from healthcare professionals to be used safely and effectively. This can occur over weeks or sometimes years. "Over three years on Fosamax, you can expect a 6% to 8% increase in spinal bone density and a 4% to 6% increase in hip bone density," says Michael Holick, MD, PhD, a . Bisphosphonates suppress the breakdown of bone, which improves bone density. You can do this with your doctor. However, if Zometa does pass into breast milk, the drug could be harmful to a breastfed child.

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