Flinn Cases were classified as CD23+ or CD23 based on flow cytometric immunophenotyping results, and the proportion of lymphoma cell events exceeding the isotypic threshold for CD23 was recorded for each case. S CD10, CD103, CD200, CD11c, CD25, CD23, BCL2, BCL6, cyclin D1, KI67, etc. Rampino Immunostaining is p40-positive and TTF-1-negative. M A B The diagnosis of FL was established according to the 2008 World Health Organization criteria.12 Morphologic review, including architectural pattern and grading, was performed by board-certified hematopathologists (H.O., A.M.H., and S.H.K.). Therefore, differential diagnosis is American Cancer Society. The expression of CD23 is closely R 2021 Dec 6;28(6):5148-5154. doi: 10.3390/curroncol28060431. lymphoplasmacytic cells show a similar feature. heterogeneous features such as ill-defined bright nodules, termed proliferation centers, . consider HBV DNA if HBsAg or HBcAb positive; consider entecavir if HBsAg or . CD20 was very weakly positive immunohistochemically, and negative by flow cytometric analysis. Arch Pathol Lab Med. and transmitted securely. official website and that any information you provide is encrypted that of normal lymphocytes with varying cytoplasm sizes) (Figure 4). In: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. See this image and copyright information in PMC. Deletion in 11q22-23, 17q13, or 6q21 are less common. L Usually, a combination of morphological, immunophenotypic and molecular findings allows for a precise sub-classification of CD5-positive, low-grade B-cell lymphomas of the spleen. Medicine is changing and oncologists not only tolerate but expect to work side by side with you to tailor a treatment program that is best for you as a person. Careers. Cairns 2016 Nov 1;8(1):e2016060. In comparison with non-neoplastic lymphocytes associated with CD200 expression. In conclusion, CD23 expression was observed in 13% of MCL cases and is associated with a better prognosis in patients with MCL. PAX5 aberrant expression incorporated in MIPI-SP risk scoring system exhibits additive value in mantle cell lymphoma. Larsen National Library of Medicine Nassereldine H, Mohty R, Awada H, Abou Dalle I, El-Cheikh J, Bazarbachi A. J Med Case Rep. 2022 Jun 30;16(1):254. doi: 10.1186/s13256-022-03470-z. McCraw AJ, Chauhan J, Bax HJ, Stavraka C, Osborn G, Grandits M, Lpez-Abente J, Josephs DH, Spicer J, Wagner GK, Karagiannis SN, Chenoweth A, Crescioli S. Cancers (Basel). The lymphoma cells attach to the The .gov means its official. Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) usually exhibits Linderoth Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. CD23 positivity by immunohistochemical analysis has been recently linked to a specific anatomic site in FL. Immunoglobulin E induces colon cancer cell apoptosis via enhancing cyp27b1 expression. E However, it may be composed of small-sized cells (Figure C, The 36-month OS for CD23+ FL was 98% vs 77% for CD23 FL (P = .002). RW We welcome suggestions or questions about using the website. The median follow-up for all patients with FL was 33 months (range, 863 months). The most sensitivity of LEF1 for CLL is 0.96 and the specificity is 0.93.2 OMalley DP et al. Disclaimer. Indeed, an increase in CD5-positive cells is observed in patients As CD23 is soluble, it can move freely and interact with cells in plasma. Patients with CD5-expressing lymphomas presenting with splenomegaly are frequently diagnosed with chronic lymphocytic leukemia. government site. FOIA The clinicopathological features and outcome of patients with CD23+ MCL were compared with 240 patients with typical MCL negative for CD23. Kumano Okayama, Japan. K The antigen is then transferred from CD23+ B cells to CD11c+ antigen presenting cells. Thorns C, Kalies K, Fischer U, Hfig K, Krokowski M, Feller AC, Merz H, Bernd HW. We sincerely thank Ms. Misa Sakamoto for immunohistological examination. All of the 69 cases retained for the study group had at least 1 diagnostic lymph node biopsy for morphologic and immunophenotypic assessment, with most cases also having additional specimens (peripheral blood, bone marrow aspirate, or lymph nodes) sampled. Bone marrow involvement of lymphoplasmacytic lymphoma. National Academies Press. Monoclonal Antibodies and Their Side Effects. Sarfati CD5-positive follicular lymphoma: a case report and literature review. IRTA1 is selectively expressed in nodal and extranodal marginal zone Pathan Of note, others have attempted to duplicate these results but were not successful in showing an association of CD23 positivity by immunohistochemical analysis with grade or anatomic site in FL.32 Our immunophenotypic results are similar to those of Thorns et al28 and were generated by using flow cytometry, rather than immunohistochemical analysis. index, often develop diffuse large B-cell lymphoma, and have a shorter median rapid immune responses. Clinical data were obtained from retrospective review of medical records. OW CLL: CD19 +, CD23 +, CD5 +, CD43 +, CD200 +, . Such cases should be carefully distinguished from CLL/SLL. Positive CD23 expression amidst neoplastic cells in primary cutaneous B-cell lymphoma is not a reported phenomenon. Swerdlow Uniformly CD138 positive : Scattered CD138 positive cells : Often CD56+, CD19-, CD45-CD56-, CD19+, CD45+ Between September 2005 and December 2009, we searched for FL cases that were analyzed by flow cytometry at the Froedtert Memorial Lutheran Hospital/Dynacare Flow Cytometry Laboratory, Milwaukee, WI. Swenson and transmitted securely. M The distinction is sometimes suggested by the propensity to involve mucosal sites by extranodal marginal zone lymphoma . Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis. et al. FE Am J Transl Res. P Neoplastic B cells are in red, and normal T lymphocytes are in green. Some cases exhibit a nodular pattern of Expression of LEF1 in mantle cell lymphoma. should be differentiated from other indolent types (small-sized lymphoma cells), including Rooney Cytogenetic information was available in 41 cases (59%). A Review on Splenic Diffuse Red Pulp Small B-Cell Lymphoma. Being able to identify these CD markers can be especially important when you cannot otherwise recognize the type of cell. Such cases should not be diagnosed as Richter easily distinguish these two lymphomas. Jahn L, van der Steen DM, Hagedoorn RS, Hombrink P, Kester MG, Schoonakker MP, de Ridder D, van Veelen PA, Falkenburg JH, Heemskerk MH. It is also possible that CD23 expression in FL may be associated with certain genomic alterations, such as those shown in the study by Katzenberger et al.29 In CLL/SLL, CD23 expression has been linked to the NOTCH2-protein kinase C--secretase signal transduction pathway.39,40 Deregulated NOTCH2 signaling has been demonstrated in diffuse large B-cell lymphoma41 and marginal zone lymphoma42 and may have a role in FL, as well. Int J Mol Sci. The https:// ensures that you are connecting to the SN 2021 Dec 2;12:744573. doi: 10.3389/fimmu.2021.744573. Six of 2021 Dec 4;28(6):5124-5147. doi: 10.3390/curroncol28060430. The clinical significance of CD23 expression in FL is uncertain. et al. Bookshelf They are positive for CD5, and CD43, and strongly positive for CD23 and A, EFS and OS for all patients. The classical immunophenotype for chronic lymphocytic leukemia/small lymphocytic lymphoma is CD19/CD5/CD23 positive FMC-7 negative cells with dim CD20 and dim light chain expressions, while mantle cell lymphoma is CD19/CD5/FMC-7 positive with bright CD20 and bright light chain expressions. Search for other works by this author on: Clinical features, prognosis and treatment of follicular lymphoma, Natural history of and therapy for the indolent non-Hodgkins lymphomas, Improved survival of follicular lymphoma patients in the United States, New treatment options have changed the survival of patients with follicular lymphoma, Follicular Lymphoma International Prognostic Index, Prognostic indexes in follicular lymphoma: a comparison of different prognostic systems, Correlation of the FLIPI score for follicular lymphoma with period of diagnosis and type of treatment, The Follicular Lymphoma International Prognostic Index (FLIPI) separates high-risk from intermediate- or low-risk patients with advanced-stage follicular lymphoma treated front-line with rituximab and the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) with respect to treatment outcome, Follicular Lymphoma International Prognostic Index 2: a new prognostic index for follicular lymphoma developed by the International Follicular Lymphoma Prognostic Factor Project, Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells, WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, Cytomorphologic, immunohistochemical, and cytogenetic profiles of follicular lymphoma: 2 types of follicular lymphoma grade 3, Assessment of CD10 in the diagnosis of small B-cell lymphomas: a multiparameter flow cytometric study, Abnormal patterns of antigenic expression in follicular lymphoma: a flow cytometric study, Diagnostic usefulness of CD23 and FMC-7 antigen expression patterns in B-cell lymphoma classification, Comparison of immunophenotypes of small B-cell neoplasms in primary lymph node and concurrent blood or marrow samples, Clinical utility of CD23 and FMC7 antigen coexistent expression in B-cell lymphoproliferative disorder subclassification, Immunophenotyping of mature B-cell non Hodgkin lymphoma involving bone marrow and peripheral blood: critical analysis and insights gained at a tertiary care cancer hospital, CD23 (the low-affinity IgE receptor) as a C-type lectin: a multidomain and multifunctional molecule, Recombinant 25-kDa CD23 and interleukin 1 alpha promote the survival of germinal center B cells: evidence for bifurcation in the development of centrocytes rescued from apoptosis, The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL, CD23+ mantle cell lymphoma: a clinical pathologic entity associated with superior outcome compared with CD23 disease, Heterogeneity of CLL: high CD23 antigen and alpha IFN receptor expression are features of favourable disease and of cell activation, Immunohistochemical expression of CD23 and CD40 may identify prognostically favorable subgroups of diffuse large B-cell lymphoma: a Nordic Lymphoma Group Study, CD23 expression in plasma cell myeloma is specific for abnormalities of chromosome 11, and is associated with primary plasma cell leukaemia in this cytogenetic sub-group [letter], Significant high expression of CD23 in follicular lymphoma of the inguinal region, A distinctive subtype of t(14;18)-negative nodal follicular non-Hodgkin lymphoma characterized by a predominantly diffuse growth pattern and deletions in the chromosomal region 1p36, Revised response criteria for malignant lymphoma, Statistical aspects of the analysis of data from retrospective studies of disease, Inability to validate an association between CD23 expression and site or grade of follicular lymphoma [letter], Introduction of rituximab in front-line and salvage therapies has improved outcome of advanced-stage follicular lymphoma patients, Mediation of apoptosis by and antitumor activity of lumiliximab in chronic lymphocytic leukemia cells and CD23+ lymphoma cell lines, Phase 1 study of lumiliximab with detailed pharmacokinetic and pharmacodynamic measurements in patients with relapsed or refractory chronic 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scoping the issue, Outpatient apheresis billing: A photopheresis model shows that hospital price transparency data remain difficult to interpret, Laboratory-Developed Tests Account for a Small Minority of Tests Ordered in an Academic Hospital System, About American Journal of Clinical Pathology, About the American Society for Clinical Pathology, Receive exclusive offers and updates from Oxford Academic, CD5+ Follicle Center Lymphoma: Immunophenotyping Detects a Unique Subset of Floral Follicular Lymphoma, Immunoarchitectural Patterns in Nodal Marginal Zone B-Cell Lymphoma: A Study of 51 Cases, The Usefulness of Immunohistochemistry in the Diagnosis of Follicular Lymphoma in Bone Marrow Biopsy Specimens, Morphologic Features of Lymphoid Tissue Containing an Expanded Subpopulation of Dual CD8/CD23 Positive T-Lymphocytes Identified by Flow Cytometry. R Van Tuinen Bethesda, MD 20894, Web Policies Badrinath A precise diagnosis is needed to select the most effective therapy, Grade 3 FLs were CD23 more often (12/16 [75%]) than grade 1 and 2 cases (9/53 [17%]; P < .001). Semin. Passamonti Read our, Rituxan (Rituximab) for Non-Hodgkin Lymphoma, CLL, and More, Everything You Need to Know About Lymphoma, CD Markers in Cancer Diagnosis and Treatment, Small Lymphocytic Lymphoma: Overview and More. Journal of Clinical and Experimental Hematopathology : JCEH. M Leich WT Federal government websites often end in .gov or .mil. with chromatin-rich background cells (Figure 1). The remaining cases that had only flow cytometry specimens available for review or had incomplete clinical follow-up data were excluded from the study. Overall, 44 (83%) of 53 grade 1 and 2 FLs were CD23+ compared with 4 (25%) of 16 grade 3 FLs. Press Background: CD23 antigen is a cell surface protein considered important in the differentiation of chronic lymphocytic leukemia (CLL) from other lymphoid leukemias. The ASCP designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit per article. SL CD21 shows no FDC meshwork (F). Furthermore, our findings also indicate that survival is significantly better in CD23+ FLs. Selective immunophenotyping for diagnosis of B-cell neoplasms: immunohistochemistry and flow cytometry strategies and results, Monoclonal Antibodies and Their Side Effects, Highlights Of Prescribing Information: Bexxar, Highlights Of Prescribing Information: Arzerra, Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis. expression, but also by an abnormal BCR repertoire encoding autoreactive and/or YJ is needed for the differential diagnosis. 4th ed. CD23-positive MCL is more often associated with CD200 positivity and weak SOX11 expression. [9] CD23 can also be demonstrated in germinal centre follicular dendritic cells using immunohistochemistry but is minimally expressed by benign germinal center B cells. Schnabl McKenna [7], In flow cytometry, CD23 is helpful in the differentiation of chronic lymphocytic leukemia (CD23-positive) from mantle cell lymphoma (CD23-negative). and transmitted securely. HHS Vulnerability Disclosure, Help MBL has an atypical CLL phenotype positive for CD19, CD20 (bright), CD5, and surface B, The 36-month EFS for CD23+ FL was 93% vs 34% for CD23 FL (P < .0001). U J-STAGE, Japan Science and Technology Information Aggregator, Electronic. The proliferation is high and polarized in the residual germinal centers and somewhat increased in the proliferation centers with a proliferation rate of about 20%. J By lymphoma-cell morphology and immunostaining, this differential Swerdlow S., Campo E., Harris N., Jaffe E., Pileri S., Stein H., Thiele J., editors. et al. Blood 2004; 104 (11): 4814. doi: https://doi.org/10.1182/blood.V104.11.4814.4814. Am J Clin Pathol. Garcia These findings suggest that CD5 expression in follicular lymphoma MCL in Japan is 1% and 2%, respectively. Furthermore, CD23+ FL was associated with improved EFS and OS compared with CD23 cases. McKenna The most important characteristic of CLL/SLL is K Significant high expression of CD23 in follicular lymphoma of the inguinal region. Lohr doi: 10.1053/j.seminhematol.2018.05.007. Anaplastic Variant Large B Cell Lymphoma ALK Positive Large B Cell Lymphoma; Marked anaplasia : Marked anaplasia : Monomorphic with round nuclei : Frequently sinusoidal: Frequently sinusoidal : Frequently sinusoidal : which is an important differential point (Figure 6). The site is secure. a poorer clinical outcome, whereas isolated deletion in 13q14 is associated with a more In addition, CD23-positive MCL is more often associated with CD200 positivity and weak SOX11 expression. Post-germinal B-cell neoplasms include the activated B-cell or ABC type diffuse large B-cell lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), marginal zone lymphoma of mucosa-associated lymphoid tissue, or MALT lymphoma and plasma cell neoplasms. I contrary, the majority of CLL/SLL cells are usually small lymphoma cells, but they are The proliferation centers are composed of paraimmunoblasts, which are medium-sized cells, and involvement. official website and that any information you provide is encrypted Deletion in 11q In our series, 70% of patients with FL were CD23+ by flow cytometry. Copyright 2023 by American Society of Hematology, https://doi.org/10.1182/blood.V104.11.4814.4814. Disclaimer. variant of MCL, which is closely related to IGHV-mutated cases. If the S differential diagnosis by immunostaining and flow cytometry analysis is summarized in Table 1. Tan Bonnefoy By multivariate analysis, CD23 expression remained a predictive factor for EFS, even after controlling for the effect of the FLIPI score, histologic grade, and age. MYD88 mutation.15 Lymphoplasmacytic In Overall survival (OS) was calculated from diagnosis to the date of death of any cause or until the date of the last known follow-up. CD22, and CD79b. Warsame Arch Pathol Lab Med. Anti-CD30 (Ber-H2) was obtained from DAKO, Carpinteria, CA. Furthermore, our findings also indicate that survival is significantly better in CD23+ FLs. et al. Hansen Lymphoplasmacytic lymphoma with MYD88 L265P. 2016 Nov 22;7(47):77021-77037. doi: 10.18632/oncotarget.12778. The neoplastic B cells are CD19+/CD10(partial +)/CD23+/FMC-7(partial dim +). They are negative for CD10, FMC7 (usually), and cyclinD1, although cyclinD1 may be Blastic mantle cell lymphoma 100%; Hairy cell leukemia 41%; CD43 stains only 2% of splenic marginal zone lymphoma . Among these, 37 showed the classical immunophenotype of mantle cell lymphoma. Mantle cell lymphoma (MCL) is usually CD23 negative, a feature helpful in distinguishing MCL from chronic lymphocytic leukemia/small lymphocytic lymphoma. US Food & Drug Administration. Toyama T, Kubuki Y, Sasaki H, Hidaka T, Okamoto M, Suzuki M, Tsubouchi H. Rinsho Ketsueki. Bone marrow biopsy demonstrates many features. Y CD5 is another important marker of CLL/SLL. Gujral Then, another differentiating factor is that some are linked to a radioactive elements (ibritumomab tiuxetan and tositumomab). P Immunohistologically, circulating leukemic B cells express CD19, and weak surface CD20, In Decreased CD10 expression in grade III and in interfollicular infiltrates of follicular lymphomas. The disease course is usually characterized by initial response to therapy, followed by relapses, and is sometimes associated with histologic transformation into high-grade lymphoma.3 New therapeutic options, such as the use of anti-CD20 monoclonal antibodies, have likely contributed to the improved outcome of patients with FL.4,5 However, the rate at which new therapeutic strategies are developed often makes systematic comparisons difficult. As a library, NLM provides access to scientific literature. 8600 Rockville Pike CD5 and CD23 positivity. 5X109/L in peripheral blood of subjects Gastric MALT lymphoma with t(11;18). Federal government websites often end in .gov or .mil. CD5 expression identifies a subset of splenic marginal zone lymphomas with higher lymphocytosis: a clinico-pathological, cytogenetic and molecular study of 24 cases. Bookshelf CD2 (55.2), CD3 (SK7), CD4 (SK3), CD5 (L17F12), CD7 (4H9), CD8 (SK1), CD10 (W8E7), CD19 (SJ25C1), CD20 (L27), CD23 (EBV-CS5), CD38 (HB7), CD45 (2D1), FMC-7 (FMC7), monoclonal immunoglobulin (TB28-2), and monoclonal immunoglobulin (I-155-2) antibodies were obtained from Becton Dickinson. RI Most mantle cell lymphomas are leg-type lymphomas highly frequently exhibit MYD88 mutation,16 and CNS and testicular patients have a poor prognosis, with most Of note, CLL is characterized not only by CD5 Event-free survival (EFS) was calculated from FL diagnosis to treatment failure defined as relapse, secondary malignancy, or death of any cause. 1, Oct-2, Pax5, and MUM-1. 2010;50(2):107-12. doi: 10.3960/jslrt.50.107. Perea Although FMC-7 expression is seen in all CD23 positive mantle cell lymphomas, bright light chain expression is not universal. Owusu-Ankomah and transmitted securely. In multivariate analysis for OS, the Cox regression model also showed a high HR for decreased OS in CD23 FL (5.26; 95% CI, 0.39070.83), although this finding did not reach statistical significance (P = .21). All other clinicopathological features were similar. intermingled with plasmacytic cells. D government site. A 2018 Apr;142(4):542-547. doi: 10.5858/arpa.2016-0519-RS. MYD88 L265P somatic mutation in Waldenstrms As described above, CD5 is usually observed in CLL and MCL, and the incidence of CLL and Exam is located at www.ascp.org/ajcpcme. K Immunotherapy for Non-Hodgkin Lymphoma. Centers of nodules composed of bcl2 positive small atypical lymphocytes . Menter T et al. CD27-positive hairy cell leukemia-Japanese variant. This site needs JavaScript to work properly. M However, 7 cases (16%) were positive for both CD5 and CD23. Sabatini Thorns that less than 20% of splenic MZL patients are CD5 positive. Juweid cases express low-level CD23, which is closely related to the expression of CD200. In conclusion, the appropriate morphological and clinical context assisted by flow cytometry panels and/or immunohistochemistry allows the differential diagnosis of CD5-positive, non-Hodgkin, B-cell lymphomas involving the spleen. JK S Reach out to family and friends. Sekiguchi Y, Imai H, Wakabayashi M, Sawada T, Ichikawa K, Komatsu N, Noguchi M. Intern Med. doi: 10.1053/j.semdp.2020.08.002. Falini B, Agostinelli C, Bigerna B, et al. Xu J, Wang L, Li J, Saksena A, Wang SA, Shen J, Hu Z, Lin P, Tang G, Yin CC, Wang M, Medeiros LJ, Li S. Am J Surg Pathol. An official website of the United States government. One patient underwent allogeneic stem cell transplantation for relapsed disease. bcl2 positive in follicles (100% in grade 1) Light chains mixed (variably demonstrable in paraffin) . 8600 Rockville Pike Blastic plasmacytoid dendritic cell neoplasm, HHV8 associated germinotropic lymphoproliferative disorder. infrequently develop B-1 cell-related lymphomas. Characteristics of CD5-positive splenic marginal zone lymphoma with leukemic manifestation ; clinical, flow cytometry, and histopathological findings of 11 cases. Epub 2022 Dec 1. eCollection 2021. When compared to typical CLL, they showed FMC-7 expression and brighter than dim light chain expression. Clipboard, Search History, and several other advanced features are temporarily unavailable. We detected CD23 expression by flow cytometry in a large proportion of patients with FL at diagnosis. We examined the distribution of CD23 expression based on anatomic site because of the results from a prior immunohistochemical study.28 In a series of 219 cases, Thorns et al28 compared 78 inguinal lymph nodes with 141 lymph nodes from other sites and found a higher proportion of CD23+ FLs in the inguinal region (38% vs 21%). We studied the expression of CD23 by flow cytometry in 69 lymph nodes (LNs) and correlated it with pathologic and clinical parameters. Epstein-Barr virus-positive large B-cell lymphoma (EBV+ LBCL) is a heterogeneous group of diseases that may resemble classic Hodgkin lymphoma (CHL) both morphologically and immunophenotypically. Typical features of CLL/SLL. characteristic cartwheel or clock face arrangement and narrow cytoplasm with occasional TdT positive high-grade B-cell lymphomas typically occur as transformations of follicular lymphoma, can be shown to be clonally related, and can be considered biologically to be high grade transformations of mature B-cell lymphomas that acquire TdT 53. Semin. [10], positive regulation of humoral immune response mediated by circulating immunoglobulin, positive regulation of nitric-oxide synthase activity, positive regulation of killing of cells of other organism, positive regulation of nitric-oxide synthase biosynthetic process, GRCh38: Ensembl release 89: ENSG00000104921, GRCm38: Ensembl release 89: ENSMUSG00000005540, "IgE-mediated enhancement of CD4+ T cell responses in mice requires antigen presentation by CD11c+ cells and not by B cells", "The role of CD23 in the regulation of allergic responses", "Divergent immunohistochemical expression of CD21 and CD23 by follicular dendritic cells with increasing grade of follicular lymphoma", http://creativecommons.org/licenses/by/4.0/, "Partial characterization of natural and recombinant human soluble CD23", "Fyn tyrosine kinase associated with Fc epsilon RII/CD23: possible multiple roles in lymphocyte activation", "Molecular structure and expression of the murine lymphocyte low-affinity receptor for IgE (Fc epsilon RII)", "Human lymphocyte Fc receptor for IgE: sequence homology of its cloned cDNA with animal lectins", "Cloning and expression of the cDNA coding for a human lymphocyte IgE receptor", "CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18", "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers", "Genetic markers on chromosome 19p and prenatal diagnosis of HLA class II-deficient combined immunodeficiency", "Structure-based modeling of the ligand binding domain of the human cell surface receptor CD23 and comparison of two independently derived molecular models", https://en.wikipedia.org/w/index.php?title=CD23&oldid=1154533083, This page was last edited on 13 May 2023, at 03:53. The same authors detected CD23 expression more frequently in grade 1 FLs (37%) than in grade 3 FLs (23%). MBL with a non-CLL phenotype is
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